The current central problem with space travel is summed up by the Tsiolkovsky rocket equation: Δv=veln(m0mf) Here, Δv is the difference between the rocket's initial and final speed, ve is the exhaust speed, m0 is the initial total mass (including propellant, payload, and the rest), and mf is the final total mass, which is everything except propellant. An efficient rocket can have an exhaust speed near 4000ms, meaning that it would need a mass ratio of around 10.5 to reach orbital speed, given drag and other losses. The ratio of structural mass to payload mass can also easily be in excess of 10, so the amount of payload a rocket can carry is really miniscule compared to its total mass.
There are a few potential approaches to this problem: